Potential role for Ginkgo biloba extract in the treatment of glaucoma
Identifieur interne : 002508 ( Main/Exploration ); précédent : 002507; suivant : 002509Potential role for Ginkgo biloba extract in the treatment of glaucoma
Auteurs : R. Ritch [États-Unis]Source :
- Medical Hypotheses [ 0306-9877 ] ; 2000.
English descriptors
- Teeft :
- Acta, Acta ophthalmol, Alzheimer type, Animal models, Antagonist, Antioxidant, Antioxidant activity, Apoptosis, Arch clin, Arch ophthalmol, Behav, Biloba, Bilobalide, Biochem, Biochem pharmacol, Biol, Blocker, Blood flow, Brain energy metabolism, Brain neurons, Braquet, Calcium channel blockers, Cerebral blood flow, Cerebral cortex, Cerebral glucose utilization, Cerebral insufficiency, Cerebrovascular insufficiency, Clin, Clin pharmacol, Clinical applications, Comparative study, Contact dermatitis, Defeudis drieu, Dementia, Diabetic rats, Doly, Drance, Drieu, Drug treatment, Elderly patients, Endothelial cells, Erythrocyte, Free radic biol, Ganglion, Ginkgo, Ginkgo biloba, Ginkgolide, Ginkgolides, Glaucoma, Glaucoma patients, Glaucomatous, Glaucomatous damage, Glucose, Glutamate, Glycogen, Glycogen synthesis, Harcourt publishers, Hippocampus, Hydrogen peroxide, Hypoxia, Infarct size, Insufficiency, Intermittent claudication, Intraocular pressure, Ischemia, Ischemic, Lipid, Lipid peroxidation, Medical hypotheses, Metabolism, Migraine, Muscle cells, Neurol, Neuron, Neuronal, Neuronal damage, Neuropathy, Neuroprotective, Neuroprotective properties, Neurosci, Neutrophil, Nitric, Ocular, Ocular blood flow, Ophthalmol, Ophthalmology, Optic, Optic nerve head, Oxidative, Oxidative metabolism, Oxidative stress, Peroxidation, Pharmacol, Pharmacol biochem behav, Placebo, Platelet, Presse, Protective effect, Receptor, Retina, Retinal ganglion cells, Risk factors, Ritch, Shields krupin, Tension glaucoma, Vestibular, Vestibular compensation, Visual field, Zingiber officinale.
Abstract
Abstract: Glaucoma is becoming recognized as a condition for which not only elevated intraocular pressure, but also non-pressure-dependent risk factors are responsible. New avenues of treatment into which investigations are being initiated include agents which could possibly improve blood flow to the eye and neuroprotective drugs. Only calcium channel blockers are presently available for such treatment in glaucoma, and these have not been widely adopted, in contrast to clinical trials involving a number of neuroprotectants in other neurologic disorders. Ginkgo biloba extract is freely available and has several biological actions which combine to make it a potentially important agent in the treatment of glaucoma: improvement of central and peripheral blood flow, reduction of vasospasm, reduction of serum viscosity, antioxidant activity, platelet activating factor inhibitory activity, inhibition of apoptosis, and inhibition of excitotoxicity. The effect of Ginkgo biloba extract as a potential antiglaucoma therapy deserves intensive scrutiny.
Url:
DOI: 10.1054/mehy.1999.0025
Affiliations:
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Ritch</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Ophthalmology, The New York Eye and Ear Infirmary, New York, NYThe New York Medical College, Valhalla, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Hypotheses</title><title level="j" type="abbrev">YMEHY</title><idno type="ISSN">0306-9877</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">54</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="221">221</biblScope><biblScope unit="page" to="235">235</biblScope></imprint><idno type="ISSN">0306-9877</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-9877</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta</term><term>Acta ophthalmol</term><term>Alzheimer type</term><term>Animal models</term><term>Antagonist</term><term>Antioxidant</term><term>Antioxidant activity</term><term>Apoptosis</term><term>Arch clin</term><term>Arch ophthalmol</term><term>Behav</term><term>Biloba</term><term>Bilobalide</term><term>Biochem</term><term>Biochem pharmacol</term><term>Biol</term><term>Blocker</term><term>Blood flow</term><term>Brain energy metabolism</term><term>Brain neurons</term><term>Braquet</term><term>Calcium channel blockers</term><term>Cerebral blood flow</term><term>Cerebral cortex</term><term>Cerebral glucose utilization</term><term>Cerebral insufficiency</term><term>Cerebrovascular insufficiency</term><term>Clin</term><term>Clin pharmacol</term><term>Clinical applications</term><term>Comparative study</term><term>Contact dermatitis</term><term>Defeudis drieu</term><term>Dementia</term><term>Diabetic rats</term><term>Doly</term><term>Drance</term><term>Drieu</term><term>Drug treatment</term><term>Elderly patients</term><term>Endothelial cells</term><term>Erythrocyte</term><term>Free radic biol</term><term>Ganglion</term><term>Ginkgo</term><term>Ginkgo biloba</term><term>Ginkgolide</term><term>Ginkgolides</term><term>Glaucoma</term><term>Glaucoma patients</term><term>Glaucomatous</term><term>Glaucomatous damage</term><term>Glucose</term><term>Glutamate</term><term>Glycogen</term><term>Glycogen synthesis</term><term>Harcourt publishers</term><term>Hippocampus</term><term>Hydrogen peroxide</term><term>Hypoxia</term><term>Infarct size</term><term>Insufficiency</term><term>Intermittent claudication</term><term>Intraocular pressure</term><term>Ischemia</term><term>Ischemic</term><term>Lipid</term><term>Lipid peroxidation</term><term>Medical hypotheses</term><term>Metabolism</term><term>Migraine</term><term>Muscle cells</term><term>Neurol</term><term>Neuron</term><term>Neuronal</term><term>Neuronal damage</term><term>Neuropathy</term><term>Neuroprotective</term><term>Neuroprotective properties</term><term>Neurosci</term><term>Neutrophil</term><term>Nitric</term><term>Ocular</term><term>Ocular blood flow</term><term>Ophthalmol</term><term>Ophthalmology</term><term>Optic</term><term>Optic nerve head</term><term>Oxidative</term><term>Oxidative metabolism</term><term>Oxidative stress</term><term>Peroxidation</term><term>Pharmacol</term><term>Pharmacol biochem behav</term><term>Placebo</term><term>Platelet</term><term>Presse</term><term>Protective effect</term><term>Receptor</term><term>Retina</term><term>Retinal ganglion cells</term><term>Risk factors</term><term>Ritch</term><term>Shields krupin</term><term>Tension glaucoma</term><term>Vestibular</term><term>Vestibular compensation</term><term>Visual field</term><term>Zingiber officinale</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Glaucoma is becoming recognized as a condition for which not only elevated intraocular pressure, but also non-pressure-dependent risk factors are responsible. New avenues of treatment into which investigations are being initiated include agents which could possibly improve blood flow to the eye and neuroprotective drugs. Only calcium channel blockers are presently available for such treatment in glaucoma, and these have not been widely adopted, in contrast to clinical trials involving a number of neuroprotectants in other neurologic disorders. Ginkgo biloba extract is freely available and has several biological actions which combine to make it a potentially important agent in the treatment of glaucoma: improvement of central and peripheral blood flow, reduction of vasospasm, reduction of serum viscosity, antioxidant activity, platelet activating factor inhibitory activity, inhibition of apoptosis, and inhibition of excitotoxicity. The effect of Ginkgo biloba extract as a potential antiglaucoma therapy deserves intensive scrutiny.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Ritch, R" sort="Ritch, R" uniqKey="Ritch R" first="R." last="Ritch">R. Ritch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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